Estimated readout windows: registry primary-completion date + 6-12 weeks. Windows already open are shown from "Now". Drug names link to ClinicalTrials.gov.
moderate to severe acute pain (incl. postoperative)(Phase 2)
Catalysts
— second half of 2026
— second half of 2027
Status note Lead candidate: oral Nav1.8 inhibitor for acute pain. Completed pivotal-design abdominoplasty trial met primary and key secondary endpoints; NDA requires a Phase 3 program plus open-label safety trial. IV formulation in development for hospital use.
LTG-321
Phase 2 · ActiveModality: small molecule (oral)
Target Nav1.8 (voltage-gated sodium channel)
Indications
chronic musculoskeletal pain (starting with knee osteoarthritis)(Phase 2)
Catalysts
— second half of 2027
Status note Next-generation Nav1.8 inhibitor, structurally distinct from onzotrigine, designed for chronic use (lower effective dose, potential once-daily). Phase 2 proof-of-concept crossover trial in knee OA (~120 patients) initiated.
LTG-418
Preclinical · ActiveModality: small molecule
Target Nav1.8 (voltage-gated sodium channel)
Indications
acute and chronic pain(Preclinical)
Status note Next-generation Nav1.8 inhibitor, structurally distinct from onzotrigine and LTG-321, predicted to have a substantially lower dose; non-GLP 14-day toxicology completed in rats and non-human primates. Additional earlier-stage Nav1.8 programs undescribed as distinct candidates.
Per-asset detail extracted from the 10-Q filed 2026-09-03. Fields the filing does not state are marked "not disclosed" rather than filled from other sources.
Sponsor-matched active trials from ClinicalTrials.gov (1 as sponsor, 0 as collaborator); "Sponsor" = company is the lead sponsor, "Collaborator" = company is a collaborator. The BP column flags big-pharma involvement as lead sponsor or collaborator (excluding the company itself). The Mgmt guide column shows what management guided for readout timing when a guided program matches the trial (hover for the quote, click for the source). Trial listings are not a company pipeline slide.