Kidney Transplant; Kidney Transplant Failure and Rejection; Immunosuppression
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Estimated readout windows: registry primary-completion date + 6-12 weeks. Windows already open are shown from "Now". Drug names link to ClinicalTrials.gov.
Status note FDA-approved, first new medicine for fibromyalgia in 15+ years. Potentially pivotal Phase 2 HORIZON study as first-line monotherapy in MDD; OASIS study for ASD/ASR funded by DoD grant.
TNX-4800
Phase 2 · ActiveModality: antibody
Aliases mAb 2217LS
Target Borrelia OspA
Partnerships UMass Chan Medical School (license)
Indications
Lyme disease prevention(Phase 2)
Catalysts
— first quarter of 2027
Status note Anti-Borrelia OspA human monoclonal antibody; Type C FDA meeting minutes support adaptive Phase 2 field study initiation.
TNX-1500
Phase 2 · ActiveModality: antibody
Target CD40L (CD154)
Partnerships Massachusetts General Hospital (investigator-initiated Phase 2)
Indications
Kidney transplant rejection(Phase 2)
Autoimmune diseases(Phase 2)
Status note Fc-modified humanized anti-CD40L (CD154) monoclonal antibody; Phase 2-ready for prevention of kidney transplant rejection and treatment of autoimmune diseases.
TNX-1300
Phase 2 · ActiveModality: enzyme
Aliases double-mutant cocaine esterase
Target cocaine
Partnerships NIH/NIDA (grant support)
Indications
Cocaine intoxication(Phase 2)
Status note FDA Breakthrough Therapy designation; Phase 2a in clinical development for cocaine intoxication.
Per-asset detail extracted from the 10-Q filed 2026-08-10. Fields the filing does not state are marked "not disclosed" rather than filled from other sources.
Sponsor-matched active trials from ClinicalTrials.gov (2 as sponsor, 4 as collaborator); "Sponsor" = company is the lead sponsor, "Collaborator" = company is a collaborator. The BP column flags big-pharma involvement as lead sponsor or collaborator (excluding the company itself). The Mgmt guide column shows what management guided for readout timing when a guided program matches the trial (hover for the quote, click for the source). Trial listings are not a company pipeline slide.